TRANSLOCATION OF IRON FROM LYSOSOMES INTO MITOCHONDRIA IS A KEY EVENT DURING OXIDATIVE STRESS-INDUCED HEPATOCELLULAR INJURY

Iron overload exacerbates various liver diseases. In hepatocytes, a portion of non-heme iron is sequestered in lysosomes and endosomes. The precise mechanisms by which lysosomal iron participates in hepatocellular injury remain uncertain. Here, our aim was to determine the role of intracellular move...

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Bibliografiske detaljer
Main Authors: Uchiyama, Akira, Kim, Jae-Sung, Kon, Kazuyoshi, Jaeschke, Hartmut, Ikejima, Kenichi, Watanabe, Sumio, Lemasters, John J.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579320/
https://ncbi.nlm.nih.gov/pubmed/18846543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.22498
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