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Syndecan-4 regulates subcellular localization of mTOR complex2 and Akt activation in a PKCα-dependent manner in endothelial cells

Mammalian target of rapamycin (mTOR) activity is regulated by assembly of two functionally distinct complexes, mTORC1 and mTORC2. In syndecan-4 (S4) null endothelial cells, mTORC2 activity is reduced, resulting in decreased Akt activation, while mTORC1 activity is increased. Levels of rictor, mLST8,...

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Detalhes bibliográficos
Main Authors: Partovian, Chohreh, Ju, Rong, Zhuang, Zhen W., Martin, Kathleen, Simons, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2578831/
https://ncbi.nlm.nih.gov/pubmed/18851840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.09.010
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