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Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner
Activation of the serine/threonine kinase Akt/PKB positively impacts on three cellular processes relevant to tumor progression: proliferation, survival, and cell size/growth. Using a three-dimensional culture model of MCF-10A mammary cells, we have examined how Akt influences the morphogenesis of po...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
The Rockefeller University Press
2003
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173511/ https://ncbi.nlm.nih.gov/pubmed/14568991 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200304159 |
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