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D(1/5) receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs

The efficacy of the D(1/5) agonist SKF38393 (100 nM-60 µM) to increase long-term potentiation (LTP) in the CA1 region was investigated in the rat hippocampal slice preparation. The receptor specificity of this enhancing effect was confirmed using the D(1/5) antagonist SKF83566 (2 µM). Although the a...

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Autors principals: Stramiello, Michael, Wagner, John J.
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2578828/
https://ncbi.nlm.nih.gov/pubmed/18644393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.06.053
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