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A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

Maintaining the appropriate complement and content of lipids in cellular membranes is critical for normal neural function. Accumulating evidence suggests that even subtle perturbations in the lipid content of neurons and myelin can disrupt their function and may contribute to myelin and axonal degra...

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Detalhes bibliográficos
Main Authors: Wheeler, David, Bandaru, Veera Venkata Ratnam, Calabresi, Peter A., Nath, Avindra, Haughey, Norman J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577809/
https://ncbi.nlm.nih.gov/pubmed/18772223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awn190
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