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Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection
The main function of regulatory T lymphocytes is to keep autoimmune responses at bay. Accordingly, it has been firmly established that the repertoire of CD4(+)CD25(+)Foxp3(+) regulatory T cells is enriched in autospecific cells. Differences in thymic positive and/or negative selection may account fo...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association of Immunologists
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577800/ https://ncbi.nlm.nih.gov/pubmed/17982064 |
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