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Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire

CD4(+)CD25(+) regulatory T lymphocytes play a crucial role in inhibition of autoimmune pathology. In accordance with this physiological role, it is now well established that the repertoire of these lymphocytes is strongly enriched in autospecific cells. However, despite extensive investigation, the...

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Bibliographische Detailangaben
Hauptverfasser: Ribot, Julie, Romagnoli, Paola, van Meerwijk, Joost PM
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association of Immunologists 2006
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346540/
https://ncbi.nlm.nih.gov/pubmed/16818767
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