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Remarkable enhancement of cytotoxicity of onconase and cepharanthine when used in combination on various tumor cell lines

Onconase (Onc), a ribonuclease from oocytes or early embryos of Northern Leopard frog (Rana pipiens), is cytostatic and cytotoxic to a variety of tumor lines in vitro, inhibits growth of tumors in animal in vivo models and is currently in Phase IIIb clinical trials for malignant mesothelioma where i...

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Detalhes bibliográficos
Main Authors: Ita, Masamichi, Halicka, H. Dorota, Tanaka, Toshiki, Kurose, Akira, Ardelt, Barbara, Shogen, Kuslima, Darzynkiewicz, Zbigniew
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577768/
https://ncbi.nlm.nih.gov/pubmed/18443430
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