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Cardioprotective Effect of Histamine H(3)-Receptor Activation: Pivotal Role of Gβγ-Dependent Inhibition of Voltage-Operated Ca(2+) Channels
We previously showed that activation of G(i/o)-coupled histamine H(3)-receptors (H(3)R) is cardioprotective since it attenuates excessive norepinephrine release from cardiac sympathetic nerves. This action is characterized by a marked decrease in intraneuronal Ca(2+) ([Ca(2+)](i)), as Gα(i) impairs...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2577049/ https://ncbi.nlm.nih.gov/pubmed/18523159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.137919 |
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