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Hypernegative Supercoiling Inhibits Growth by Causing RNA Degradation

Transcription-induced hypernegative supercoiling is a hallmark of Escherichia coli topoisomerase I (topA) mutants. However, its physiological significance has remained unclear. Temperature downshift of a mutant yielded transient growth arrest and a parallel increase in hypernegative supercoiling tha...

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Sonraí Bibleagrafaíochta
Main Authors: Baaklini, Imad, Usongo, Valentine, Nolent, Flora, Sanscartier, Patrick, Hraiky, Chadi, Drlica, Karl, Drolet, Marc
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology (ASM) 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576660/
https://ncbi.nlm.nih.gov/pubmed/18790862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00680-08
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