Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation

Gyrase-mediated hypernegative supercoiling is one manifestation of R-loop formation, a phenomenon that is normally suppressed by topoisomerase I (topA) in Escherichia coli. Overproduction of RNase HI (rnhA), an enzyme that removes the RNA moiety of R-loops, prevents hypernegative supercoiling and al...

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Main Authors: Usongo, Valentine, Nolent, Flora, Sanscartier, Patrick, Tanguay, Cynthia, Broccoli, Sonia, Baaklini, Imad, Drlica, Karl, Drolet, Marc
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2875999/
https://ncbi.nlm.nih.gov/pubmed/18554330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06334.x
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