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Hypernegative Supercoiling Inhibits Growth by Causing RNA Degradation
Transcription-induced hypernegative supercoiling is a hallmark of Escherichia coli topoisomerase I (topA) mutants. However, its physiological significance has remained unclear. Temperature downshift of a mutant yielded transient growth arrest and a parallel increase in hypernegative supercoiling tha...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2576660/ https://ncbi.nlm.nih.gov/pubmed/18790862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00680-08 |
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