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Inhibition of Gluconeogenesis in Primary Hepatocytes by Stromal Cell-derived Factor-1 (SDF-1) through a c-Src/Akt-dependent Signaling Pathway

Hepatic gluconeogenesis is elevated in diabetes and a major contributor to hyperglycemia. Stromal cell-derived factor-1 (SDF-1) is a chemokine and an activator of Akt. In this study, we tested the hypothesis that SDF-1 suppresses hepatic gluconeogenesis through Akt. Our results from isolated primary...

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Detalhes bibliográficos
Main Authors: Liu, Hui-Yu, Wen, Ge-Bo, Han, Jianmin, Hong, Tao, Zhuo, Degen, Liu, Zhenqi, Cao, Wenhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576540/
https://ncbi.nlm.nih.gov/pubmed/18786922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M803698200
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