Aldosterone Stimulates Elastogenesis in Cardiac Fibroblasts via Mineralocorticoid Receptor-independent Action Involving the Consecutive Activation of Gα(13), c-Src, the Insulin-like Growth Factor-I Receptor, and Phosphatidylinositol 3-Kinase/Akt

We previously demonstrated that aldosterone, which stimulates collagen production through the mineralocorticoid receptor (MR)-dependent pathway, also induces elastogenesis via a parallel MR-independent mechanism involving insulin-like growth factor-I receptor (IGF-IR) signaling. The present study pr...

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Main Authors: Bunda, Severa, Wang, Yanting, Mitts, Thomas F., Liu, Peter, Arab, Sara, Arabkhari, Majid, Hinek, Aleksander
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Glycobiology and Extracellular Matrices
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713569/
https://ncbi.nlm.nih.gov/pubmed/19372600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008748
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