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Aldosterone Stimulates Elastogenesis in Cardiac Fibroblasts via Mineralocorticoid Receptor-independent Action Involving the Consecutive Activation of Gα(13), c-Src, the Insulin-like Growth Factor-I Receptor, and Phosphatidylinositol 3-Kinase/Akt
We previously demonstrated that aldosterone, which stimulates collagen production through the mineralocorticoid receptor (MR)-dependent pathway, also induces elastogenesis via a parallel MR-independent mechanism involving insulin-like growth factor-I receptor (IGF-IR) signaling. The present study pr...
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主要な著者: | , , , , , , |
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フォーマット: | Artigo |
言語: | Inglês |
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American Society for Biochemistry and Molecular Biology
2009
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主題: | |
オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2713569/ https://ncbi.nlm.nih.gov/pubmed/19372600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.008748 |
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