A C-terminal Fragment of Cyclin E, Generated by Caspase-mediated Cleavage, Is Degraded in the Absence of a Recognizable Phosphodegron

We have previously shown that caspase-mediated cleavage of Cyclin E generates p18-Cyclin E in hematopoietic tumor cells. Its expression can induce apoptosis or sensitize to apoptotic stimuli in many cell types. However, p18-cyclin E has a much shorter half-life than Cyclin E, being more effectively...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Plesca, Dragos, Mazumder, Suparna, Gama, Vivian, Matsuyama, Shigemi, Almasan, Alexandru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2008
Pynciau:
Protein Synthesis, Post-Translational Modification, and Degradation
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576529/
https://ncbi.nlm.nih.gov/pubmed/18784078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M804642200
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