Subcutaneous late phase responses are augmented during local inhalational tolerance in a murine asthma model

Acute exposure of sensitized mice to antigen elicits allergic airway disease (AAD) characterized by Th2 cytokine-dependent pulmonary eosinophilia, methacholine hyperresponsiveness and antigen-specific IgE elevation. However, chronic exposure induces a local inhalational tolerance (LIT), with resolut...

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Autores principales: Singh, Anurag, Thrall, Roger S, Guernsey, Linda A, Carson, William F, Secor, Eric R, Cone, Robert E, Rajan, Thiruchandurai V, Schramm, Craig M
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576509/
https://ncbi.nlm.nih.gov/pubmed/18458679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/icb.2008.32
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