Repair of Topoisomerase I-Mediated DNA Damage

Topoisomerase I (Top1) is an abundant and essential enzyme. Top1 is the selective target of camptothecins, which are effective anticancer agents. Top1-DNA cleavage complexes can also be trapped by various endogenous and exogenous DNA lesions including mismatches, abasic sites and carcinogenic adduct...

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Autors principals: Pommier, Yves, Barcelo, Juana, Rao, V. Ashutosh, Sordet, Olivier, Jobson, Andrew G., Thibaut, Laurent, Miao, Zheyong, Seiler, Jennifer, Zhang, Hongliang, Marchand, Christophe, Agama, Keli, Redon, Christophe
Format: Artigo
Idioma:Inglês
Publicat: 2006
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576451/
https://ncbi.nlm.nih.gov/pubmed/16891172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0079-6603(06)81005-6
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