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Repair of Topoisomerase I-Mediated DNA Damage
Topoisomerase I (Top1) is an abundant and essential enzyme. Top1 is the selective target of camptothecins, which are effective anticancer agents. Top1-DNA cleavage complexes can also be trapped by various endogenous and exogenous DNA lesions including mismatches, abasic sites and carcinogenic adduct...
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| 主要な著者: | , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2576451/ https://ncbi.nlm.nih.gov/pubmed/16891172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0079-6603(06)81005-6 |
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