Simulations of Skin Barrier Function: Free Energies of Hydrophobic and Hydrophilic Transmembrane Pores in Ceramide Bilayers

Transmembrane pore formation is central to many biological processes such as ion transport, cell fusion, and viral infection. Furthermore, pore formation in the ceramide bilayers of the stratum corneum may be an important mechanism by which penetration enhancers such as dimethylsulfoxide (DMSO) weak...

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Main Authors: Notman, Rebecca, Anwar, Jamshed, Briels, W. J., Noro, Massimo G., den Otter, Wouter K.
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2008
Teme:
Membranes
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576386/
https://ncbi.nlm.nih.gov/pubmed/18708461
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.138545
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