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Free energy of hydrophilic and hydrophobic pores in lipid bilayers by free energy perturbation of a restraint

The free energy of pore formation in lipid bilayers has been previously calculated using a variety of reaction coordinates. Here, we use free energy perturbation of a cylindrical lipid exclusion restraint to compute the free energy profile as a function of pore radius in dimyristoylphosphatidylcholi...

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Detalhes bibliográficos
Publicado no:J Chem Phys
Main Authors: Dixit, Mayank, Lazaridis, Themis
Formato: Artigo
Idioma:Inglês
Publicado em: AIP Publishing LLC 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7928062/
https://ncbi.nlm.nih.gov/pubmed/32770888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/5.0016682
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