Soluble Amyloid β-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity

It is well established that Alzheimer's amyloid β-peptides reduce the membrane barrier to ion transport. The prevailing model ascribes the resulting interference with ion homeostasis to the formation of peptide pores across the bilayer. In this work, we examine the interaction of soluble prefib...

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Main Authors: Valincius, Gintaras, Heinrich, Frank, Budvytyte, Rima, Vanderah, David J., McGillivray, Duncan J., Sokolov, Yuri, Hall, James E., Lösche, Mathias
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2008
Fag:
Supramolecular Assemblies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576380/
https://ncbi.nlm.nih.gov/pubmed/18515395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130997
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