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Soluble Amyloid β-Oligomers Affect Dielectric Membrane Properties by Bilayer Insertion and Domain Formation: Implications for Cell Toxicity

It is well established that Alzheimer's amyloid β-peptides reduce the membrane barrier to ion transport. The prevailing model ascribes the resulting interference with ion homeostasis to the formation of peptide pores across the bilayer. In this work, we examine the interaction of soluble prefib...

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Detalhes bibliográficos
Main Authors: Valincius, Gintaras, Heinrich, Frank, Budvytyte, Rima, Vanderah, David J., McGillivray, Duncan J., Sokolov, Yuri, Hall, James E., Lösche, Mathias
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576380/
https://ncbi.nlm.nih.gov/pubmed/18515395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.130997
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