Fas-mediated elimination of antigen-presenting cells and autoreactive T cells contribute to prevention of autoimmunity

SUMMARY: Fas (Apo-1, CD95) receptor has been suggested to control T cell expansion by triggering T cell-autonomous apoptosis. This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice and humans lacking Fas or its ligand. However, with systemic loss of Fas, it is...

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Hauptverfasser: Stranges, Peter. B., Watson, Jessica, Cooper, Cristie J., Choisy-Rossi, Caroline-Morgane, Stonebraker, Austin C., Beighton, Ryan A., Hartig, Heather, Sundberg, John P., Servick, Stein, Kaufmann, Gunnar, Fink, Pamela J., Chervonsky, Alexander V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575811/
https://ncbi.nlm.nih.gov/pubmed/17509906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.03.016
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