Fas-mediated elimination of antigen-presenting cells and autoreactive T cells contribute to prevention of autoimmunity

SUMMARY: Fas (Apo-1, CD95) receptor has been suggested to control T cell expansion by triggering T cell-autonomous apoptosis. This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice and humans lacking Fas or its ligand. However, with systemic loss of Fas, it is...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stranges, Peter. B., Watson, Jessica, Cooper, Cristie J., Choisy-Rossi, Caroline-Morgane, Stonebraker, Austin C., Beighton, Ryan A., Hartig, Heather, Sundberg, John P., Servick, Stein, Kaufmann, Gunnar, Fink, Pamela J., Chervonsky, Alexander V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575811/
https://ncbi.nlm.nih.gov/pubmed/17509906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2007.03.016
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