Serine/threonine kinase-protein kinase B and extracellular signal-regulated kinase regulate ventilator-induced pulmonary fibrosis after bleomycin-induced acute lung injury: a prospective, controlled animal experiment

INTRODUCTION: Lung fibrosis, reduced lung compliance, and severe hypoxemia found in patients with acute lung injury often result in a need for the support of mechanical ventilation. High-tidal-volume mechanical ventilation can increase lung damage and fibrogeneic activity but the mechanisms regulati...

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Main Authors: Li, Li-Fu, Liao, Shuen-Kuei, Huang, Chung-Chi, Hung, Ming-Jui, Quinn, Deborah A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575592/
https://ncbi.nlm.nih.gov/pubmed/18691424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc6983
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