Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays

INTRODUCTION: In critically ill patients, the massive release of angiopoietin-2 (Ang-2) from endothelial Weibel–Palade bodies interferes with constitutive angiopoietin-1 (Ang-1)/Tie2 signaling in endothelial cells, thus leading to vascular barrier breakdown followed by leukocyte transmigration and c...

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Main Authors: Lukasz, Alexander, Hellpap, Julian, Horn, Rüdiger, Kielstein, Jan T, David, Sascha, Haller, Hermann, Kümpers, Philipp
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575578/
https://ncbi.nlm.nih.gov/pubmed/18664247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc6966
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