Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons

Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with excitotoxicity and nociception. Inhibition of P2X7R activation has been considered as a potentially useful strategy to improve recovery from spinal cord injury and reduce inflammatory damage to trauma. The physiological functi...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Yong, Zhang, Xiaofei, Wang, Congying, Li, GuangWen, Gu, Yanping, Huang, Li-Yen Mae
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2008
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575495/
https://ncbi.nlm.nih.gov/pubmed/18946042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801793105
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