Activation of P2X7 receptors in glial satellite cells reduces pain through downregulation of P2X3 receptors in nociceptive neurons

Purinergic ionotropic P2X7 receptors (P2X7Rs) are closely associated with excitotoxicity and nociception. Inhibition of P2X7R activation has been considered as a potentially useful strategy to improve recovery from spinal cord injury and reduce inflammatory damage to trauma. The physiological functi...

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Autors principals: Chen, Yong, Zhang, Xiaofei, Wang, Congying, Li, GuangWen, Gu, Yanping, Huang, Li-Yen Mae
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575495/
https://ncbi.nlm.nih.gov/pubmed/18946042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0801793105
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