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A critical role of the cAMP sensor Epac in switching protein kinase signalling in prostaglandin E2-induced potentiation of P2X3 receptor currents in inflamed rats

Sensitization of purinergic P2X receptors is one of the mechanisms responsible for exaggerated pain responses to inflammatory injuries. Prostaglandin E2 (PGE2), produced by inflamed tissues, is known to contribute to abnormal pain states. In a previous study, we showed that PGE2 increases fast inact...

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Detalhes bibliográficos
Main Authors: Wang, Congying, Gu, Yanping, Li, Guang-Wen, Huang, Li-Yen Mae
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2277053/
https://ncbi.nlm.nih.gov/pubmed/17702820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2007.135616
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