The ubiquitin ligase Siah2 regulates tumorigenesis and metastasis by HIF-dependent and -independent pathways

The ubiquitin ligase Siah2 has been shown to regulate prolyl hydroxylase 3 (PHD3) stability with concomitant effect on HIF-1α availability. Because HIF-1α is implicated in tumorigenesis and metastasis, we used SW1 mouse melanoma cells, which develop primary tumors with a propensity to metastasize, i...

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Bibliographic Details
Main Authors: Qi, Jianfei, Nakayama, Koh, Gaitonde, Supriya, Goydos, James S., Krajewski, Stan, Eroshkin, Alexey, Bar-Sagi, Dafna, Bowtell, David, Ronai, Ze'ev
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575485/
https://ncbi.nlm.nih.gov/pubmed/18946040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804063105
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