How the thymus designs antigen-specific and self-tolerant T cell receptor sequences

T lymphocytes (T cells) orchestrate adaptive immune responses that clear pathogens from infected hosts. T cells recognize short peptides (p) derived from antigenic proteins bound to protein products of the MHC genes. Recognition occurs when T cell receptor (TCR) proteins expressed on T cells bind su...

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Bibliografske podrobnosti
Main Authors: Košmrlj, Andrej, Jha, Abhishek K., Huseby, Eric S., Kardar, Mehran, Chakraborty, Arup K.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Physical Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575478/
https://ncbi.nlm.nih.gov/pubmed/18946038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0808081105
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