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Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

Adherence of parasitized erythrocytes to activated endothelium causes microvascular obstruction, tissue ischemia, and clinical complications in severe malaria (SM); however, the mechanisms leading to endothelial activation remain unclear. The angiogenic factors, angiopoietin-2 (Ang-2) and vascular e...

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Detalhes bibliográficos
Main Authors: Yeo, Tsin W., Lampah, Daniel A., Gitawati, Retno, Tjitra, Emiliana, Kenangalem, Enny, Piera, Kim, Price, Ric N., Duffull, Stephen B., Celermajer, David S., Anstey, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575222/
https://ncbi.nlm.nih.gov/pubmed/18957536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805782105
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