A Randomized Pilot Study of L-Arginine Infusion in Severe Falciparum Malaria: Preliminary Safety, Efficacy and Pharmacokinetics

BACKGROUND: Decreased nitric oxide (NO) and hypoargininemia are associated with severe falciparum malaria and may contribute to severe disease. Intravenous L-arginine increases endothelial NO in moderately-severe malaria (MSM) without adverse effects. The safety, efficacy and pharmacokinetics of L-a...

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Detalhes bibliográficos
Main Authors: Yeo, Tsin W., Lampah, Daniel A., Rooslamiati, Indri, Gitawati, Retno, Tjitra, Emiliana, Kenangalem, Enny, Price, Ric N., Duffull, Stephen B., Anstey, Nicholas M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726665/
https://ncbi.nlm.nih.gov/pubmed/23922746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069587
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