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Regulation of Chk1 by Its C-terminal Domain
Chk1 is a protein kinase that is the effector molecule in the G2 DNA damage checkpoint. Chk1 homologues have an N-terminal kinase domain, and a C-terminal domain of ∼200 amino acids that contains activating phosphorylation sites for the ATM/R kinases, though the mechanism of activation remains unkno...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2575178/ https://ncbi.nlm.nih.gov/pubmed/18716058 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-04-0444 |
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