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Regulatory motifs in Chk1
Chk1 is the effector kinase of the G(2) DNA damage checkpoint. Chk1 homologs possess a highly conserved N-terminal kinase domain and a less conserved C-terminal regulatory domain. In response to DNA damage, Chk1 is recruited to mediator proteins assembled at lesions on replication protein A (RPA)-co...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3637350/ https://ncbi.nlm.nih.gov/pubmed/23422000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23881 |
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