Assembly and Misassembly of Cystic Fibrosis Transmembrane Conductance Regulator: Folding Defects Caused by Deletion of F508 Occur Before and After the Calnexin-dependent Association of Membrane Spanning Domain (MSD) 1 and MSD2

Cystic fibrosis transmembrane conductance regulator (CFTR) is a polytopic membrane protein that functions as a Cl(−) channel and consists of two membrane spanning domains (MSDs), two cytosolic nucleotide binding domains (NBDs), and a cytosolic regulatory domain. Cytosolic 70-kDa heat shock protein (...

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Hauptverfasser: Rosser, Meredith F. N., Grove, Diane E., Chen, Liling, Cyr, Douglas M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575159/
https://ncbi.nlm.nih.gov/pubmed/18716059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-04-0357
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