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Conformational Changes in the Metallo-β-lactamase ImiS During the Catalytic Reaction: an EPR Spectrokinetic Study of Co(II)-Spin Label Interactions
Metallo-β-lactamases are responsible for conferring antibiotic resistance on certain pathogenic bacteria. In consequence, the search for inhibitors that may be useful in combating antibiotic resistance has fueled much study of the active sites of these enzymes. There exists circumstantial evidence t...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574873/ https://ncbi.nlm.nih.gov/pubmed/18528987 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja0774562 |
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