Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression, decreased BAK activation, and not by ERBB receptor mutation

We have defined some of the mechanisms by which the kinase inhibitor Lapatinib kills HCT116 cells. Lapatinib inhibited radiation-induced activation of ERBB1/2, ERK1/2 and AKT, and radiosensitized HCT116 cells. Prolonged incubation of HCT116 cells with Lapatinib caused cell killing followed by outgro...

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Autores principales: Martin, Aditi Pandya, Miller, Anna, Emad, Luni, Rahmani, Mohammed, Walker, Teneille, Mitchell, Clint, Hagan, Michael P., Park, Margaret A., Yacoub, Adly, Fisher, Paul B., Grant, Steven, Dent, Paul
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574656/
https://ncbi.nlm.nih.gov/pubmed/18544666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.108.047365
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