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Integrated Cellular Bone Homeostasis Model for Denosumab Pharmacodynamics in Multiple Myeloma Patients

The purpose of this study is to couple a cellular bone homeostasis model with the pharmacokinetics (PK) and mechanism of action of denosumab, an inhibitor of receptor activator of nuclear factor-κB ligand, to characterize the time course of serum N-telopeptide (NTX), a bone resorption biomarker, fol...

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Detalhes bibliográficos
Main Authors: Marathe, Anshu, Peterson, Mark C., Mager, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574593/
https://ncbi.nlm.nih.gov/pubmed/18460643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.137703
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