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Kinetic Analysis of Interaction of BRCA1 Tandem Breast Cancer C-Terminal Domains with Phosphorylated Peptides Reveals Two Binding Conformations

Tandem breast cancer C-terminal (BRCT) domains, present in many DNA repair and cell cycle checkpoint signaling proteins, are phosphoprotein binding modules. The best-characterized tandem BRCT domains to date are from the protein BRCA1 (BRCA1-BRCT), an E3 ubiquitin ligase that has been linked to brea...

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Detalhes bibliográficos
Main Authors: Nominé, Yves, Botuyan, Maria Victoria, Bajzer, Zeljko, Owen, Whyte G., Caride, Ariel J., Wasielewski, Emeric, Mer, Georges
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574583/
https://ncbi.nlm.nih.gov/pubmed/18717574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi702247d
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