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Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis
The last few steps in the biosynthesis of the anticancer drug Taxol in yew (Taxus) species are thought to involve the attachment of β-phenylalanine to the C13-O-position of the advanced taxane diterpenoid intermediate baccatin III to yield N-debenzoyl-2′-deoxytaxol, followed by hydroxylation on the...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2574419/ https://ncbi.nlm.nih.gov/pubmed/18621016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2008.06.021 |
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