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O-phospho-L-serine, multi-functional excipient for B domain deleted recombinant factor VIII

Factor VIII (FVIII) is an important cofactor in the blood coagulation cascade. A deficiency or dysfunction of FVIII causes hemophilia A, a life-threatening bleeding disorder. FVIII circulates in plasma as a heterodimer comprising 6 domains (heavy chain, A1-A2-B and light chain A3-C1-C2). Replacement...

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Sonraí Bibleagrafaíochta
Main Authors: Miclea, Razvan D., Purohit, Vivek S., Balu-Iyer, Sathy V.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Springer-Verlag 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573386/
https://ncbi.nlm.nih.gov/pubmed/17907766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj0902028
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