Identification of Direct Transcriptional Targets of the Kaposi's Sarcoma-Associated Herpesvirus Rta Lytic Switch Protein by Conditional Nuclear Localization

Lytic reactivation from latency is critical for the pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). We previously demonstrated that the 691-amino-acid (aa) KSHV Rta transcriptional transactivator is necessary and sufficient to reactivate the virus from latency. Viral lytic cycle...

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Detalhes bibliográficos
Main Authors: Bu, Wei, Palmeri, Diana, Krishnan, Raghu, Marin, Roxana, Aris, Virginie M., Soteropoulos, Patricia, Lukac, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573185/
https://ncbi.nlm.nih.gov/pubmed/18715905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01012-08
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