Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

Prion diseases such as scrapie involve the accumulation of disease-specific prion protein, PrP(Sc), in the brain. Toll-like receptors (TLRs) are a family of proteins that recognize microbial constituents and are central players in host innate immune responses. The TLR9 agonist unmethylated CpG DNA w...

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Główni autorzy: Spinner, Daryl S., Cho, In Soo, Park, Seung Yong, Kim, Jae Il, Meeker, Harry C., Ye, Xuemin, LaFauci, Giuseppe, Kerr, Daniel J., Flory, Michael J., Kim, Bo Sook, Kascsak, Regina B., Wisniewski, Thomas, Levis, William R., Schuller-Levis, Georgia B., Carp, Richard I., Park, Eunkyue, Kascsak, Richard J.
Format: Artigo
Język:Inglês
Wydane: American Society for Microbiology (ASM) 2008
Hasła przedmiotowe:
Pathogenesis and Immunity
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573175/
https://ncbi.nlm.nih.gov/pubmed/18715916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00522-08
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