Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

Prion diseases such as scrapie involve the accumulation of disease-specific prion protein, PrP(Sc), in the brain. Toll-like receptors (TLRs) are a family of proteins that recognize microbial constituents and are central players in host innate immune responses. The TLR9 agonist unmethylated CpG DNA w...

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Detalhes bibliográficos
Main Authors: Spinner, Daryl S., Cho, In Soo, Park, Seung Yong, Kim, Jae Il, Meeker, Harry C., Ye, Xuemin, LaFauci, Giuseppe, Kerr, Daniel J., Flory, Michael J., Kim, Bo Sook, Kascsak, Regina B., Wisniewski, Thomas, Levis, William R., Schuller-Levis, Georgia B., Carp, Richard I., Park, Eunkyue, Kascsak, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573175/
https://ncbi.nlm.nih.gov/pubmed/18715916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00522-08
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