Differential Modulation of prM Cleavage, Extracellular Particle Distribution, and Virus Infectivity by Conserved Residues at Nonfurin Consensus Positions of the Dengue Virus pr-M Junction

In the generation of flavivirus particles, an internal cleavage of the envelope glycoprotein prM by furin is required for the acquisition of infectivity. Unlike cleavage of the prM of other flaviviruses, cleavage of dengue virus prM is incomplete in many cell lines; the partial cleavage reflects the...

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Bibliographic Details
Main Authors: Junjhon, Jiraphan, Lausumpao, Matthawee, Supasa, Sunpetchuda, Noisakran, Sansanee, Songjaeng, Adisak, Saraithong, Prakaimuk, Chaichoun, Kridsada, Utaipat, Utaiwan, Keelapang, Poonsook, Kanjanahaluethai, Amornrat, Puttikhunt, Chunya, Kasinrerk, Watchara, Malasit, Prida, Sittisombut, Nopporn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2008
Subjects:
Structure and Assembly
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573171/
https://ncbi.nlm.nih.gov/pubmed/18715923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01180-08
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