Hitchhiking and Selective Sweeps of Plasmodium falciparum Sulfadoxine and Pyrimethamine Resistance Alleles in a Population from Central Africa

Sulfadoxine-pyrimethamine (SP) resistance in Plasmodium falciparum is encoded by a number of mutations in the dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) genes. Here, we have characterized point mutations in dhfr and dhps and microsatellite loci around dhfr on chromosome 4 a...

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Bibliografiske detaljer
Main Authors: McCollum, Andrea M., Basco, Leonardo K., Tahar, Rachida, Udhayakumar, Venkatachalam, Escalante, Ananias A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573158/
https://ncbi.nlm.nih.gov/pubmed/18765692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00623-08
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