Decline in Sulfadoxine-Pyrimethamine-Resistant Alleles after Change in Drug Policy in the Amazon Region of Peru

The frequency of alleles with triple mutations conferring sulfadoxine-pyrimethamine (SP) resistance in the Peruvian Amazon Basin has declined (16.9% for dhfr and 0% for dhps compared to 47% for both alleles in 1997) 5 years after SP was replaced as the first-line treatment for Plasmodium falciparum...

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Detalhes bibliográficos
Main Authors: Zhou, Zhiyong, Griffing, Sean M., de Oliveira, Alexandre Macedo, McCollum, Andrea M., Quezada, Wilmer Marquino, Arrospide, Nancy, Escalante, Ananias A., Udhayakumar, Venkatachalam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224716/
https://ncbi.nlm.nih.gov/pubmed/18025120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00975-07
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