Gq-Dependent Signaling Upregulates COX2 in Glomerular Podocytes

Accumulating evidence suggests that upregulation of cyclooxygenase 2 (COX2) in glomerular podocytes promotes podocyte injury. Because Gq signaling activates calcineurin and calcineurin-dependent mechanisms are known to mediate COX2 expression, this study investigated the role of Gqα in promoting COX...

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Autors principals: Wang, Liming, Flannery, Patrick J., Rosenberg, Paul B., Fields, Timothy A., Spurney, Robert F.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2008
Matèries:
Basic Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573009/
https://ncbi.nlm.nih.gov/pubmed/18667730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2008010113
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