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Efficient cell-free production of olfactory receptors: Detergent optimization, structure, and ligand binding analyses
High-level production of membrane proteins, particularly of G protein-coupled receptors (GPCRs) in heterologous cell systems encounters a number of difficulties from their inherent hydrophobicity in their transmembrane domains, which frequently cause protein aggregation and cytotoxicity and thus red...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2572932/ https://ncbi.nlm.nih.gov/pubmed/18840687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804766105 |
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